Additional file 1 of A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population

Additional file 1: Supplement Figure 1. Isolated TumorMap of the batch-integrated normal breast transcriptomes overlain with color-scaled intensity scores (red = high) for their various epithelial attributes including % epithelial nuclei, TDLU scores, KIT and TRPS1 gene expression levels. All numeric sample scores can be found in Supplement Table 4. Supplement Figure 2. Isolated TumorMap of the batch-integrated normal breast transcriptomes overlain with color-scaled intensity scores (red = high) for their various tissue compositions (% stromal, adipocyte, epithelial nuclei) and transcriptome gene expression modules representing specific immune cell signatures (macrophage, CD68, CD8 Tcell). Modules are defined in Supplement Table 1 and their numeric signature scores are listed in Supplement Table 4. Supplement Figure 3. Normal breast expression of genes representing adipocyte activation, remodeling, and pro-inflammatory signaling for all P batch samples according to their sample transcriptome phenotype assignment as either Active or Inactive (as described in Fig. 4 legend).