MOESM2 of MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

Additional file 2: Table S1. Genes exhibiting significantly different expression changes in 501mel cells in response to AZD6244 treatment. Table S2. The 250 pigmentation genes with differential expression in 501mel cells under AZD6244 treatment. Genes associated with H3K27ac loss or gain regions by GREAT analysis, or with SOX10 binding sites under AZD6244 are also indicated. Table S3. Top 5 significantly enriched transcription factor motifs identified by de novo motif enrichment analysis of genomic regions that were losing or gaining H3K27ac in 501mel cells in response to AZD6244 treatment. Table S4. The 799 super-enhancers identified in 501mel cells treated with DMSO only, and the 583 super-enhancers identified in 501mel cells treated with AZD6244. Table S5. Top enriched biological processes from GO analyses of 1080 genes associated with super-enhancers in control (DMSO-treated) 501mel cells. Table S6. Super-enhancer-associated pigmentation genes with significant expression changes following AZD6244 treatment. Table S7. GWAS loci associated with pigmentation and/or melanoma phenotypes that overlap with H3K27ac regions and/or with SOX10 binding sites.