MOESM2 of Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Additional file 2: Figure S1. Autophagy gene expression in multiple region of AD brains. Figure S2. Loss of NRBF2 reduces ULK1-FIP200 interaction and is rescued upon NRBF2-viruses transduction. Figure S3. Brain regional analysis of NRBF2 and autophagy markers expression. Figure S4. No anxious or anxiolytic behavior is observed in NRBF2-KO mice. Figure S5. Loss of NRBF2 in 5XFAD mice promotes memory deficits and enhances Aβ aggregation. Figure S6. Pre- and post-synaptic markers expression is unchanged in NRBF2-KO hippocampi. Figure S7. Upregulation of AMPK activity inhibits mTORC1 signaling in hippocampus of NRBF2-KO mice. Figure S8. Level of cleaved-caspase 3 is not changed in hippocampus of NRBF2 KO mice.