MOESM1 of Effects of exenatide and open-label SGLT2 inhibitor treatment, given in parallel or sequentially, on mortality and cardiovascular and renal outcomes in type 2 diabetes: insights from the EXSCEL trial

Additional file 1: Table S1. Total participant-years of SGLT2i exposure in the full EXSCEL trial by drug and trial arm. Table S2. Pre-match clinical characteristics of EXSCEL participants at trial baseline. Table S3. Detailed events, follow-up durations, and hazard ratios for exenatide + SGLT2i vs. placebo comparison in propensity-matched cohorts. Table S4. Detailed events, follow-up durations, and hazard ratios for exenatide + SGLT2i vs. exenatide comparison in propensity-matched cohorts. Table S5. Time-to-event exenatide QW + SGLT2i vs. placebo comparison in propensity-matched cohorts with overlapping SGLT2i and study drug use. Table S6. Time-to-event exenatide QW + SGLT2i vs. exenatide QW comparison in propensity-matched cohorts with overlapping SGLT2i and study drug use. Table S7. Time-to-event exenatide QW + SGLT2i vs. placebo comparison in propensity-matched cohorts censoring at open-label GLP-1 RA use. Table S8. Time-to-event exenatide QW + SGLT2i vs. exenatide QW comparison in propensity- matched cohorts censoring at open-label GLP-1 RA use. Figure S1. Participant flow chart. Figure S2. SGLT2i and study drug usage details. Figure S3. Balance of confounders before and after propensity matching. Figure S4. Propensity score distributions before and after matching. Figure S5. Kaplan–Meier curves for MACE, nonfatal MI, and nonfatal stroke. Figure S6. Kaplan–Meier curves for ACM and CV death. Figure S7. Kaplan–Meier curves for HHF and HHF + CV death. Figure S8. Kaplan–Meier curves for renal composites. Figure S9. Kaplan–Meier curves for serious hypoglycemia and amputation. Figure S10. Distributions of hazard ratio estimates when matching is repeated. Figure S11. Geometric mean (+/− standard error) eGFR slope before and after matching in the propensity-matched cohorts.