Additional file 5: of Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice

Male mice have increased plasma insulin levels on HFD. Column graphs showing plasma insulin levels in chow- and HFD-fed male and female mice. (a) Significant increases in insulin levels were seen in male WT, Crhr2−/−, and Crhr2+/− mice (HFD vs. chow, n = 9/group). (b) HFD intake did not significantly increase plasma insulin levels in female WT, Crhr2−/−, and Crhr2+/− mice (n = 9/group). Three-way ANOVA and post hoc Tukey’s multiple comparisons. (DOCX 310 kb)