Additional file 1 of UHPLC-MS/MS profiling of histidine and bile acid metabolism in human gastric fluid for diagnosis of gastric diseases

Additional file 1: Supplementary Fig. 1. Serial derivatization procedures to primary amine and carboxylate groups on HIST, His, and BAs. Supplementary Fig. 2. MRM chromatograms of HIST, His, and 5 BAs according to derivatization order: (A) DMED-Bz derivatization and (B) Bz-DMED derivatization. SupplementaryFig. 3. MRM chromatograms of HIST, His, 5 BAs, and their corresponding internal standards in SGF (10 μg/mL for His and 1 μg/mL for HIST and 5 BAs) Supplementary Table 1. MRM transitions and parameters. Supplementary Table S2. Derivatization yields for HIST, His, and BAs.