Additional file 1: of Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

Hayden, Eric; Putman, Jennifer; Nunez, Stefanie; Shin, Woo; Oberoi, Mandavi; Charreton, Malena; Dutta, Suman; Li, Zizheng; Komuro, Yutaro; Joy, Mary; Bitan, Gal; MacKenzie-Graham, Allan; Jiang, Lin; Hinman, Jason

doi:10.6084/m9.figshare.9698222.v1

40478_2019_783_MOESM1_ESM.docx (25.4 MB)

Additional file 1: of Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

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posted on 2019-08-21, 04:29 authored by Eric Hayden, Jennifer Putman, Stefanie Nunez, Woo Shin, Mandavi Oberoi, Malena Charreton, Suman Dutta, Zizheng Li, Yutaro Komuro, Mary Joy, Gal Bitan, Allan MacKenzie-Graham, Lin Jiang, Jason Hinman

Figure S1. Retrograde neuronal labeling after subcortical stroke. Figure S2. MACS-FACS isolation of CTIP2+ Layer 5 cortical neurons after stroke. Figure S3. Gene expression differences in stroke-injured MACS-FACS isolated CTIP2+ neurons. Figure S4. Mark4 potentiates tau aggregation in a biosensor assay. Figure S5. Effect of Mark enzymatic inhibition on tau aggregation. (DOCX 25706 kb)

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National Institute of Neurological Disorders and Stroke

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Stroke Ischemia Subcortical stroke White matter Tau Mark4

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Additional file 1: of Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

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