#Translated into .psc from madonna format FIX: Asp S_Adenosyl_Methionine sink # Keywords Description: AspPathway Output_In_Conc: True Species_In_Conc: True # GlobalUnitDefinitions UnitSubstance: mole, 1.0, 0, 1 UnitArea: metre, 1.0, 0, 2 UnitVolume: litre, 1.0, 0, 1 UnitLength: metre, 1.0, 0, 1 UnitTime: second, 1.0, 0, 1 # Reactions v_1: Asp = AspP AKI*(AKI_kforward_app_exp - AKI_kreverse_app_exp*AspP)*1/(1+(Thr/ AKI_Thr_Ki_app_exp)**AKI_h_exp) v_2: Asp = AspP AKII*(AKII_kforward_app_exp - AKII_kreverse_app_exp*AspP)/(1+(Thr/ AKII_Thr_Ki_app_exp)**AKII_h_exp) v_3: Asp = AspP AK2*(AK2_kforward_app_exp - AK2_kreverse_app_exp*AspP)/(1+(Lys/ AK2_Lys_Ki_app_exp)**AK2_h_exp) v_4: Asp = AspP AK1*(AK1_kforward_app_exp - AK1_kreverse_app_exp*AspP)/(1+(Lys/(AK1_Lys_Ki_app_exp/(1+S_Adenosyl_Methionine/AK1_AdoMet_Ka_app_exp)))**AK1_h_exp) v_6: ASA > Hser HSDHI* HSDHI_kforward_app_exp *ASA*( HSDHI_Thr_relative_residual_activity_app_exp+HSDHI_Thr_relative_inhibition_app_exp /(1+Thr/ HSDHI_Thr_Ki_app_exp)) v_5: AspP > ASA ASADH*(ASADH_kforward_app_exp*AspP- ASADH_kreverse_app_exp*ASA) v_7: ASA > Hser HSDHII* HSDHII_kforward_app_exp *ASA*( HSDHII_Thr_relative_residual_activity_app_exp+HSDHII_Thr_relative_inhibition_app_exp /(1+Thr/ HSDHII_Thr_Ki_app_exp)) v_8: Hser > PHser HSK*HSK_kcat_app_exp*Hser/(HSK_Hser_app_exp + Hser) v_9: PHser > Thr TS1*(TS1_kcatmin_exp + TS1_AdoMet_kcatmax_exp*S_Adenosyl_Methionine**TS1_h_exp / TS1_AdoMet_Ka1_exp)/(1+S_Adenosyl_Methionine**TS1_h_exp / TS1_AdoMet_Ka1_exp)*PHser/((1+Phos/TS1_Phosphate_Ki_exp)*( TS1_AdoMEt_Km_no_AdoMet_exp*(1+S_Adenosyl_Methionine/ TS1_AdoMet_Ka2_exp)/(1+S_Adenosyl_Methionine/ TS1_AdoMet_Ka3_exp))/(1+S_Adenosyl_Methionine**TS1_h_exp /TS1_AdoMet_Ka4_exp)+PHser) v_10: Thr > Ile TD*TD_k_app_exp*Thr/(1+(Ile/( TD_Ile_Ki_no_Val_app_exp + TD_Val_Ka1_app_exp *Val/( TD_Val_Ka2_app_exp +Val)))**TD_h_app_exp) v_11: Thr > sink Thr_tRNAS_Vmax *Thr/(Thr_tRNAS_Thr_Km+Thr) v_12: Ile > sink Ile_tRNAS_Vmax *Ile/(Ile_tRNAS_Ile_Km+Ile) v_13: PHser > S_Adenosyl_Methionine CGS*(CGS_kcat_exp /(1+ CGS_Cys_Km_exp /Cys))*PHser/(( CGS_Phser_Km_exp /(1+ CGS_Cys_Km_exp /Cys))*(1+Phos/ CGS_Phosphate_Ki_exp)+ PHser) v_14: ASA > Lys DHDPS1* DHDPS1_k_app_exp*ASA*(1/(1+(Lys/DHDPS1_Lys_Ki_app_exp)**DHDPS1_h_exp)) v_15: ASA > Lys DHDPS2* DHDPS2_k_app_exp *ASA*(1/(1+(Lys/ DHDPS2_Lys_Ki_app_exp)**DHDPS2_h_exp)) # additional reactions inferred from Madonna file v_16: Lys > sink Lys_tRNAS_Vmax *Lys/(Lys_tRNAS_Lys_Km+Lys) #Vtha: # Thr > sink # THA*THA_kcat_exp*Thr/(THA_Thr_Km_exp+Thr) #Vlkr: # Lys > sink # LKR*LKR_kcat_exp*Lys/(LKR_Lys_Km_exp+Lys) ## ####### ## # Variable species Ile = 0.0 Val = 100.0 ASADH = 11.6 Thr = 0.0 AspP = 0.0 Phos = 10000.0 DHDPS2 = 1.6 DHDPS1 = 1.6 Hser = 0.0 TD = 0.36 Cys = 15.0 Asp = 150.0 Lys = 0.0 AK2 = 0.25 AK1 = 0.25 PHser = 0.0 AKII = 0.63 HSDHII = 0.63 ASA = 0.0 AKI = 0.63 HSDHI = 0.63 S_Adenosyl_Methionine = 20.0 HSK = 4.0 CGS = 0.7 TS1 = 7.4 # Parameters AK1_kforward_app_exp = 5.65 AK1_kreverse_app_exp = 1.60 AK1_Lys_Ki_app_exp = 550.0 AK1_AdoMet_Ka_app_exp = 3.5 AK1_h_exp = 2.0 AK2_kforward_app_exp = 3.15 AK2_kreverse_app_exp = 0.86 AK2_Lys_Ki_app_exp = 22.0 AK2_h_exp = 1.1 AKI_kforward_app_exp = 0.36 AKI_kreverse_app_exp = 0.15 AKI_Thr_Ki_app_exp = 124.0 AKI_h_exp = 2.6 AKII_kforward_app_exp = 1.35 AKII_kreverse_app_exp = 0.22 AKII_Thr_Ki_app_exp = 109.0 AKII_h_exp = 2.0 ASADH_kforward_app_exp = 0.9 ASADH_kreverse_app_exp = 0.23 DHDPS1_k_app_exp = 1.0 DHDPS1_Lys_Ki_app_exp = 10.0 DHDPS1_h_exp = 2.0 DHDPS2_k_app_exp = 1.0 DHDPS2_Lys_Ki_app_exp = 33.0 DHDPS2_h_exp = 2.0 HSDHI_kforward_app_exp = 0.84 HSDHI_Thr_relative_residual_activity_app_exp = 0.15 HSDHI_Thr_relative_inhibition_app_exp = 0.85 HSDHI_Thr_Ki_app_exp = 400.0 HSDHII_kforward_app_exp = 0.64 HSDHII_Thr_relative_residual_activity_app_exp = 0.25 HSDHII_Thr_relative_inhibition_app_exp = 0.75 HSDHII_Thr_Ki_app_exp = 8500.0 HSK_kcat_app_exp = 2.8 HSK_Hser_app_exp = 14.0 TS1_kcatmin_exp = 0.42 TS1_AdoMet_kcatmax_exp = 3.5 TS1_AdoMet_Ka1_exp = 73.0 TS1_h_exp = 2.0 TS1_Phosphate_Ki_exp = 1000.0 TS1_AdoMEt_Km_no_AdoMet_exp = 250.0 TS1_AdoMet_Ka2_exp = 0.5 TS1_AdoMet_Ka3_exp = 1.09 TS1_AdoMet_Ka4_exp = 142.0 CGS_kcat_exp = 30.0 CGS_Cys_Km_exp = 460.0 CGS_Phser_Km_exp = 2500.0 CGS_Phosphate_Ki_exp = 2000.0 TD_k_app_exp = 0.0124 TD_Ile_Ki_no_Val_app_exp = 30.0 TD_Val_Ka1_app_exp = 73.0 TD_Val_Ka2_app_exp = 615.0 TD_h_app_exp = 3.0 sink = 0.0 Lys_tRNAS_Vmax = 0.43 Lys_tRNAS_Lys_Km = 25.0 Ile_tRNAS_Vmax = 0.43 Ile_tRNAS_Ile_Km = 20.0 Thr_tRNAS_Vmax = 0.43 Thr_tRNAS_Thr_Km = 100.0 THA = 0.0 THA_kcat_exp = 1.7 THA_Thr_Km_exp = 7100.0 LKR = 0.0 LKR_kcat_exp = 3.1 LKR_Lys_Km_exp = 13000.0