rGO nanomaterial-mediated cancer targeting and photothermal therapy in a microfluidic co-culture platform
Posted on 2020-03-17 - 04:41
Abstract We developed the microfluidic co-culture platform to study photothermal therapy applications. We conjugated folic acid (FA) to target breast cancer cells using reduced graphene oxide (rGO)-based functional nanomaterials. To characterize the structure of rGO-based nanomaterials, we analyzed the molecular spectrum using UV–visible and Fourier-transform infrared spectroscopy (FT-IR). We demonstrated the effect of rGO-FA-based nanomaterials on photothermal therapy of breast cancer cells in the microfluidic co-culture platform. From the microfluidic co-culture platform with breast cancer cells and human umbilical vein endothelial cells (HUVECs), we observed that the viability of breast cancer cells treated with rGO-FA-based functional nanomaterials was significantly decreased after near-infrared (NIR) laser irradiation. Therefore, this microfluidic co-culture platform could be a potentially powerful tool for studying cancer cell targeting and photothermal therapy.
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Mun, Seok Gyu; Choi, Hyung Woo; Lee, Jong Min; Lim, Jae Hyun; Ha, Jang Ho; Kang, Min-Jung; et al. (2020). rGO nanomaterial-mediated cancer targeting and photothermal therapy in a microfluidic co-culture platform. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4896729.v1
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AUTHORS (9)
SM
Seok Gyu Mun
HC
Hyung Woo Choi
JL
Jong Min Lee
JL
Jae Hyun Lim
JH
Jang Ho Ha
MK
Min-Jung Kang
EK
Eun-Joong Kim
LK
Lifeng Kang
BC
Bong Geun Chung