Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus
Posted on 2019-10-08 - 05:24
Abstract This report describes the detection of a triple reassortant swine influenza A virus of H1avN2 subtype. It evolved from an avian-like swine H1avN1 that first acquired the N2 segment from a seasonal H3N2, then the M segment from a 2009 pandemic H1N1, in two reassortments estimated to have occurred 10 years apart. This study illustrates how recurrent influenza infections increase the co-infection risk and facilitate evolutionary jumps by successive gene exchanges. It recalls the importance of appropriate biosecurity measures inside holdings to limit virus persistence and interspecies transmissions, which both contribute to the emergence of new potentially zoonotic viruses.
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Chastagner, Amélie; Bonin, Emilie; Fablet, Christelle; Quéguiner, Stéphane; Hirchaud, Edouard; Lucas, Pierrick; et al. (2019). Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4690307.v1
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AUTHORS (14)
AC
Amélie Chastagner
EB
Emilie Bonin
CF
Christelle Fablet
SQ
Stéphane Quéguiner
EH
Edouard Hirchaud
PL
Pierrick Lucas
SG
Stéphane Gorin
NB
Nicolas Barbier
VB
Véronique Béven
EG
Emmanuel Garin
YB
Yannick Blanchard
NR
Nicolas Rose
SH
Séverine Hervé
GS
Gaëlle Simon
KEYWORDS
reassortant swine influenzaVirus persistenceco-infection riskH 3Nreassortment events2009 pandemic H 1N10 yearszoonotic virusesH 1avN subtypebiosecurity measuresgene exchangesavian-like swine H 1avNinfluenza infections increasenovel triple-reassortant swine influenza virus Abstractemergencepig herdslimit virus persistenceinterspecies transmissionsM segmentN 2 segment