Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors
Posted on 2020-01-15 - 05:10
Abstract Background Atherosclerotic cardiovascular (CV) events commonly occur in individuals with a low CV risk burden. This study evaluated the ability of the triglyceride glucose (TyG) index to predict subclinical coronary artery disease (CAD) in asymptomatic subjects without traditional CV risk factors (CVRFs). Methods This retrospective, cross-sectional, and observational study evaluated the association of TyG index with CAD in 1250 (52.8 ± 6.5 years, 46.9% male) asymptomatic individuals without traditional CVRFs (defined as systolic/diastolic blood pressure ≥ 140/90 mmHg; fasting glucose ≥126 mg/dL; total cholesterol ≥240 mg/dL; low-density lipoprotein cholesterol ≥160 mg/dL; high-density lipoprotein cholesterol < 40 mg/dL; body mass index ≥25.0 kg/m2; current smoking; and previous medical history of hypertension, diabetes, or dyslipidemia). CAD was defined as the presence of any coronary plaque on coronary computed tomographic angiography. The participants were divided into three groups based on TyG index tertiles. Results The prevalence of CAD increased with elevating TyG index tertiles (group I: 14.8% vs. group II: 19.3% vs. group III: 27.6%; P < 0.001). Multivariate logistic regression models showed that TyG index was associated with an increased risk of CAD (odds ratio [OR] 1.473, 95% confidence interval [CI] 1.026–2.166); especially non-calcified (OR 1.581, 95% CI 1.002–2.493) and mixed plaques (OR 2.419, 95% CI 1.051–5.569) (all P < 0.05). The optimal TyG index cut-off for predicting CAD was 8.44 (sensitivity 47.9%; specificity 68.5%; area under the curve 0.600; P < 0.001). The predictive value of this cut-off improved after considering the non-modifiable factors of old age and male sex. Conclusions TyG index is an independent marker for predicting subclinical CAD in individuals conventionally considered healthy.
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Park, Gyung-Min; Cho, Young-Rak; Won, Ki-Bum; Yang, Yu; Park, Sangwoo; Ann, Soe; et al. (2020). Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4817805.v1
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AUTHORS (17)
GP
Gyung-Min Park
YC
Young-Rak Cho
KW
Ki-Bum Won
YY
Yu Yang
SP
Sangwoo Park
SA
Soe Ann
YK
Yong-Giun Kim
EP
Eun Park
SK
Shin-Jae Kim
SL
Sang-Gon Lee
DY
Dong Yang
JK
Joon-Won Kang
TL
Tae-Hwan Lim
HK
Hong-Kyu Kim
JC
Jaewon Choe
SL
Seung-Whan Lee
YK
Young-Hak Kim