The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Re, Francesca

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Posted on 2019-11-12 - 05:03

Abstract We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

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Formicola, Beatrice; Dal Magro, Roberta; Montefusco-Pereira, Carlos; Lehr, Claus-Michael; Koch, Marcus; Russo, Laura; et al. (2019). The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4734320.v1

https://doi.org/10.6084/m9.figshare.c.4734320.v1

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