The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS
Posted on 2019-11-13 - 05:05
Abstract Background Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD. Methods Sputum and plasma samples were obtained from COPD participants in the SPIROMICS cohort at enrollment. AcPGP was isolated using solid phase extraction and measured by mass spectrometry. Demographics, spirometry, quality of life questionnaires, and quantitative computed tomography (CT) imaging with parametric response mapping (PRM) were obtained at baseline. Severe COPD exacerbations were recorded at 1-year of prospective follow-up. We used linear and logistic regression models to measure associations between AcPGP and features of COPD, and Kaplan-Meier analyses to measure time-to-first severe exacerbation. Results The 182 COPD participants in the analysis were 66 ± 8 years old, 62% male, 84% White race, and 39% were current smokers. AcPGP concentrations were 0.61 ± 1.89 ng/mL (mean ± SD) in sputum and 0.60 ± 1.13 ng/mL in plasma. In adjusted linear regression models, sputum AcPGP was associated with FEV1/FVC, spirometric GOLD stage, PRM-small airways disease, and PRM-emphysema. Sputum AcPGP also correlated with severe AECOPD, and elevated sputum AcPGP was associated with shorter time-to-first severe COPD exacerbation. In contrast, plasma AcPGP was not associated with symptoms, pulmonary function, or severe exacerbation risk. Conclusions In COPD, sputum but not plasma AcPGP concentrations are associated with the severity of airflow limitation, small airways disease, emphysema, and risk for severe AECOPD at 1-year of follow-up. Trial registration ClinicalTrials.gov: NCT01969344 (SPIROMICS).
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Wells, J.; Xing, Dongqi; Viera, Liliana; Burkes, Robert; Wu, Yixin; Bhatt, Surya; et al. (2019). The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4736891.v1
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AUTHORS (19)
JW
J. Wells
DX
Dongqi Xing
LV
Liliana Viera
RB
Robert Burkes
YW
Yixin Wu
SB
Surya Bhatt
MD
Mark Dransfield
DC
David Couper
WO
Wanda O’Neal
EH
Eric Hoffman
AG
Amit Gaggar
IB
Igor Barjaktarevic
JC
Jeffrey Curtis
WL
Wassim Labaki
MH
Mei Han
CF
Christine Freeman
NP
Nirupama Putcha
TS
Thomas Schlange
JB
J. Blalock