The economic burden of systemic sclerosis related pulmonary arterial hypertension in Australia
Posted on 2019-11-28 - 04:59
Abstract Background To quantify the financial cost of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods Healthcare use was captured through data linkage, wherein clinical data for SSc patients enrolled in the Australian Scleroderma Cohort Study were linked with hospital, emergency department (ED) and ambulatory care databases (MBS) for the period 2008–2015. PAH was diagnosed on right heart catheter according to international criteria. Determinants of healthcare cost were estimated using logistic regression. Results Total median (25th–75th) healthcare cost per patient (including hospital, ED and MBS cost but excluding medication cost) for our cohort during 2008–2015 was AUD$37,685 (18,144-78,811) with an annual per patient healthcare cost of AUD$7506 (5273-10,654). Total healthcare cost was higher for SSc-PAH patients compared with those without PAH with a total cost per patient of AUD$70,034 (37,222-110,814) vs AUD$34,325 (16,093 – 69,957), p < 0.001 respectively with an annual excess healthcare cost per PAH patient of AUD$2463 (1973-1885), p < 0.001. The cost of SSc-PAH occurs early post PAH diagnosis with 89.4% utilizing a healthcare service within the first 12 months post PAH diagnosis with an associated cost per patient of AUD$4125 (0–15,666). PAH severity was the main significant determinant of increased healthcare cost (OR 2.5, p = 0.03) in our PAH cohort. Conclusions Despite SSc-PAH being a low prevalence disease, it is associated with significant healthcare resource utilization and associated economic burden, predominantly driven by the severity of PAH.
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Morrisroe, Kathleen; Stevens, Wendy; Sahhar, Joanne; Ngian, Gene-Siew; Ferdowsi, Nava; Hansen, Dylan; et al. (2019). The economic burden of systemic sclerosis related pulmonary arterial hypertension in Australia. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4762397.v1
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AUTHORS (12)
KM
Kathleen Morrisroe
WS
Wendy Stevens
JS
Joanne Sahhar
GN
Gene-Siew Ngian
NF
Nava Ferdowsi
DH
Dylan Hansen
SP
Shreeya Patel
CH
Catherine Hill
JR
Janet Roddy
JW
Jennifer Walker
SP
Susanna Proudman
MN
Mandana Nikpour