The association of metabolic syndrome components and chronic kidney disease in patients with hypertension
Posted on 2019-12-28 - 04:35
Abstract Background Hypertension is a highly prevalent disease and the leading cause of chronic kidney disease (CKD). Metabolic syndrome could also be the risk factor for CKD. We sought to study the association between metabolic syndrome components and the prevalence of CKD in patients with hypertension. Methods We carried out a multi-center cross-sectional study from Apr. 2017- Apr. 2018 in 15 cities in China. Results A total of 2484 patients with hypertension were enrolled. Among them, 56% were male and the average age was 65.12 ± 12.71 years. The systolic BP/diastolic BP was 142 ± 18/83 ± 12 mmHg. Metabolic syndrome components turned out to be highly prevalent in patients with hypertension, ranging from 40 to 58%. The prevalence of chronic kidney disease reached 22.0%. Multi-variate logistic analysis revealed that elevated triglyceride (TG) (OR = 1.81, 95% CI 1.28–2.57, p < 0.01), elevated fasting blood glucose (FBG) (OR = 1.43, 95% CI 1.00–2.07, p = 0.05) and hypertension grades (OR = 1.20, 95% CI 1.00–1.44, p = 0.05) were associated with the prevalence of CKD. In sub-group analysis, elevated TG remained strongly associated with CKD in both diabetes (OR = 2.10, 95%CI 1.22–3.61, p < 0.01) and non-diabetes (OR = 1.53, 95% CI 1.09–2.16, p = 0.01). In sub-group analysis of hypertension grades, there was also a graded trend between elevated TG and CKD from controlled blood pressure (BP) to hypertension grade 2 (OR = 1.81, 95%CI 1.06–3.11, p = 0.03; OR = 1.85, 95%CI 1.00–3.43, p = 0.05; OR = 2.81, 95% CI 1.09–7.28, p = 0.03, respectively). Conclusion Elevated TG, elevated FBG and hypertension grades were significantly associated with the prevalence of CKD in patients with hypertension. Particularly, elevated TG was strongly associated with CKD, independent of diabetes and hypertension grades.
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Xie, Kun; Bao, Liwen; Jiang, Xiaofei; Ye, Zi; Bing, Jianping; Dong, Yugang; et al. (2019). The association of metabolic syndrome components and chronic kidney disease in patients with hypertension. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4799409.v1
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AUTHORS (26)
KX
Kun Xie
LB
Liwen Bao
XJ
Xiaofei Jiang
ZY
Zi Ye
JB
Jianping Bing
YD
Yugang Dong
DG
Danchen Gao
XJ
Xiaoping Ji
TJ
Tingbo Jiang
JL
Jiehua Li
YL
Yan Li
SL
Suxin Luo
WM
Wei Mao
DP
Daoquan Peng
PQ
Peng Qu
SS
Shangming Song
HW
Hui Wang
ZW
Zhaohui Wang
BX
Biao Xu
XY
Xinhua Yin