The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany
Posted on 2018-02-20 - 05:00
Abstract Background Multidrug-resistant bacteria represent a substantial global burden for human health, potentially fuelled by migration waves: in 2015, 476,649 refugees applied for asylum in Germany mostly as a result of the Syrian crisis. In Arabic countries, multiresistant bacteria cause significant problems for healthcare systems. Currently, no data exist describing antibiotic resistances in healthy refugees. Here, we assess the microbial landscape and presence of antibiotic resistance genes (ARGs) in refugees and German controls. To achieve this, a systematic study was conducted in 500 consecutive refugees, mainly from Syria, Iraq, and Afghanistan and 100 German controls. Stool samples were subjected to PCR-based quantification of 42 most relevant ARGs, 16S ribosomal RNA gene sequencing-based microbiota analysis, and culture-based validation of multidrug-resistant microorganisms. Results The fecal microbiota of refugees is substantially different from that of resident Germans. Three categories of resistance profiles were found: (i) ARGs independent of geographic origin of individuals comprising BIL/LAT/CMA, ErmB, and mefE; (ii) vanB with a high prevalence in Germany; and (iii) ARGs showing substantially increased prevalences in refugees comprising CTX-M group 1, SHV, vanC1, OXA-1, and QnrB. The majority of refugees carried five or more ARGs while the majority of German controls carried three or less ARGs, although the observed ARGs occurred independent of signatures of potential pathogens. Conclusions Our results, for the first time, assess antibiotic resistance genes in refugees and demonstrate a substantially increased prevalence for most resistances compared to German controls. The antibiotic resistome in refugees may thus require particular attention in the healthcare system of host countries.
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Häsler, Robert; Kautz, Christian; Rehman, Ateequr; Podschun, Rainer; Gassling, Volker; Brzoska, Pius; et al. (2018). The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4009726.v1
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AUTHORS (23)
RH
Robert Häsler
CK
Christian Kautz
AR
Ateequr Rehman
RP
Rainer Podschun
VG
Volker Gassling
PB
Pius Brzoska
JS
Jon Sherlock
JG
Jan-Thorsten Gräsner
GH
Gesine Hoppenstedt
SS
Sabine Schubert
AF
Astrid Ferlinz
WL
Wolfgang Lieb
ML
Matthias Laudes
FH
Femke-Anouska Heinsen
JS
Jens Scholz
DH
Dag Harmsen
AF
Andre Franke
SE
Swantje Eisend
TK
Thomas Kunze
HF
Helmut Fickenscher