TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
Posted on 2020-04-03 - 03:47
Abstract We present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of TAD splits and mergers between pairs of different cell types, such as endothelial cells and fibroblasts. Our work reveals a key role for TAD remodeling in epigenetic regulation of transcription and delivers the first tool for the community to perform dynamic analysis of TAD splits and mergers in numerous biological and disease models.
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Wang, Guangyu; Meng, Qingshu; Xia, Bo; Zhang, Shuo; Lv, Jie; Zhao, Dongyu; et al. (2020). TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4920906.v1
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AUTHORS (12)
GW
Guangyu Wang
QM
Qingshu Meng
BX
Bo Xia
SZ
Shuo Zhang
JL
Jie Lv
DZ
Dongyu Zhao
YL
Yanqiang Li
XW
Xin Wang
LZ
Lili Zhang
JC
John P. Cooke
QC
Qi Cao
KC
Kaifu Chen