Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives
Posted on 2019-08-07 - 04:23
Abstract We have synthesized new series of bisindole analogs (1–27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 µM respectively when compared with standard pentamidine with IC50 value of 7.20 ± 0.20 µM. All analogs showed greater potential than standard except 10, 19 and 23 when compared with standard. Structure activity relationship has been also established for all compounds. Molecular docking studies were carried out to understand the binding interaction of active molecules.
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Taha, Muhammad; Uddin, Imad; Gollapalli, Mohammed; Almandil, Noor; Rahim, Fazal; Farooq, Rai; et al. (2019). Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4609778.v1
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AUTHORS (11)
MT
Muhammad Taha
IU
Imad Uddin
MG
Mohammed Gollapalli
NA
Noor Almandil
FR
Fazal Rahim
RF
Rai Farooq
MN
Muhammad Nawaz
MI
Mohamed Ibrahim
MA
Mohammed Alqahtani
YB
Yasser Bamarouf
MS
Manikandan Selvaraj