Structural changes of cerebellum and brainstem in migraine without aura
Posted on 2019-09-03 - 04:41
Abstract Background Increasing evidence has suggested that the cerebellum is associated with pain and migraine. In addition, the descending pain system of the brainstem is the major site of trigeminal pain processing and modulation and has been discussed as a main player in the pathophysiology of migraine. Cerebellar and brainstem structural changes associated with migraineurs remain to be further investigated. Methods Voxel-based morphometry (VBM) (50 controls, 50 migraineurs without aura (MWoAs)) and diffusion tensor imaging (DTI) (46 controls, 46 MWoAs) were used to assess cerebellum and brainstem anatomical alterations associated with MWoAs. We utilized a spatially unbiased infratentorial template toolbox (SUIT) to perform cerebellum and brainstem optimized VBM and DTI analysis. We extracted the average diffusion values from a probabilistic cerebellar white matter atlas to investigate whether MWoAs exhibited microstructure alterations in the cerebellar peduncle tracts. Results MWoAs showed decreased fractional anisotropy (FA) in the vermis VI extending to the bilateral lobules V and VI of the cerebellum. We also found higher axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) in the right inferior cerebellum peduncle tract in MWoAs. MWoAs exhibited both reduced gray matter volume and increased AD, MD and RD in the spinal trigeminal nucleus (SpV). Conclusion MWoAs exhibited microstructural changes in the cerebellum and the local brainstem. These structural differences might contribute to dysfunction of the transmission and modulation of noxious information, trigeminal nociception, and conduction and integration of multimodal information in MWoAs. These findings further suggest involvement of the cerebellum and the brainstem in the pathology of migraine without aura.
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Qin, Zhaoxia; He, Xin-Wei; Zhang, Jilei; Xu, Shuai; Li, Ge-Fei; Su, Jingjing; et al. (2019). Structural changes of cerebellum and brainstem in migraine without aura. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4651727.v1
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AUTHORS (16)
ZQ
Zhaoxia Qin
XH
Xin-Wei He
JZ
Jilei Zhang
SX
Shuai Xu
GL
Ge-Fei Li
JS
Jingjing Su
YS
Yan-Hui Shi
SB
Shiyu Ban
YH
Yue Hu
YL
Yi-Sheng Liu
MZ
Mei-Ting Zhuang
RZ
Rong Zhao
XS
Xiao-Lei Shen
JL
Jianqi Li
JL
Jian-Ren Liu
XD
Xiaoxia Du