Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
Posted on 2020-05-20 - 03:52
Abstract Background Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). Conclusion Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
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Whitmire, Paula; Rickertsen, Cassandra R.; Hawkins-Daarud, Andrea; Carrasco, Eduardo; Lorence, Julia; De Leon, Gustavo; et al. (2020). Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4985450.v1
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Cassandra R. Rickertsen
Gustavo De Leon
Noah C. Peeri
Christine Paula Lewis-de los Angeles
Bernard R. Bendok
Maciej M. Mrugala
Leland S. Hu