Seroprevalence of SARS-CoV-2 antibodies in social housing areas in Denmark

Posted on 11.02.2022 - 04:24
Abstract Background COVID-19 is thought to be more prevalent among ethnic minorities and individuals with low socioeconomic status. We aimed to investigate the prevalence of SARS-CoV-2 antibodies during the COVID-19 pandemic among citizens 15 years or older in Denmark living in social housing (SH) areas. Methods We conducted a study between January 8th and January 31st, 2021 with recruitment in 13 selected SH areas. Participants were offered a point-of-care rapid SARS-CoV-2 IgM and IgG antibody test and a questionnaire concerning risk factors associated with COVID-19. As a proxy for the general Danish population we accessed data on seroprevalence from Danish blood donors (total Ig ELISA assay) in same time period. Results Of the 13,279 included participants, 2296 (17.3%) were seropositive (mean age 46.6 (SD 16.4) years, 54.2% female), which was 3 times higher than in the general Danish population (mean age 41.7 (SD 14.1) years, 48.5% female) in the same period (5.8%, risk ratios (RR) 2.96, 95% CI 2.78–3.16, p > 0.001). Seropositivity was higher among males (RR 1.1, 95% CI 1.05–1.22%, p = 0.001) and increased with age, with an OR seropositivity of 1.03 for each 10-year increase in age (95% CI 1.00–1.06, p = 0.031). Close contact with COVID-19-infected individuals was associated with a higher risk of infection, especially among household members (OR 5.0, 95% CI 4.1–6.2 p < 0,001). Living at least four people in a household significantly increased the OR of seropositivity (OR 1.3, 95% CI 1.0–1.6, p = 0.02) as did living in a multi-generational household (OR 1.3 per generation, 95% CI 1.1–1.6, p = 0.003). Only 1.6% of participants reported not following any of the national COVID-19 recommendations. Conclusions Danish citizens living in SH areas of low socioeconomic status had a three times higher SARS-CoV-2 seroprevalence compared to the general Danish population. The seroprevalence was significantly higher in males and increased slightly with age. Living in multiple generations households or in households of more than four persons was a strong risk factor for being seropositive. Results of this study can be used for future consideration of the need for preventive measures in the populations living in SH areas.

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Fogh, Kamille; Eriksen, Alexandra R. R.; Hasselbalch, Rasmus B.; Kristensen, Emilie Sofie; Bundgaard, Henning; Nielsen, Susanne D.; et al. (2022): Seroprevalence of SARS-CoV-2 antibodies in social housing areas in Denmark. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5837485.v1
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AUTHORS (35)

Kamille Fogh
Alexandra R. R. Eriksen
Rasmus B. Hasselbalch
Emilie Sofie Kristensen
Henning Bundgaard
Susanne D. Nielsen
Charlotte S. Jørgensen
Bibi F. S. S. Scharff
Christian Erikstrup
Susanne G. Sækmose
Dorte K. Holm
Bitten Aagaard
Jakob Norsk
Pernille Brok Nielsen
Jonas H. Kristensen
Lars Østergaard
Svend Ellermann-Eriksen
Berit Andersen
Henrik Nielsen
Isik S. Johansen
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