Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study
Posted on 2020-10-22 - 03:30
Abstract Background Prior studies reported that 5 ~ 32% COVID-19 patients were critically ill, a situation that poses great challenge for the management of the patients and ICU resources. We aim to identify independent risk factors to serve as prediction markers for critical illness of SARS-CoV-2 infection. Methods Fifty-two critical and 200 non-critical SARS-CoV-2 nucleic acid positive patients hospitalized in 15 hospitals outside Wuhan from January 19 to March 6, 2020 were enrolled in this study. Multivariable logistic regression and LASSO logistic regression were performed to identify independent risk factors for critical illness. Results Age older than 60 years, dyspnea, respiratory rate > 24 breaths per min, leukocytosis > 9.5 × 109/L, neutrophilia > 6.3 × 109/L, lymphopenia < 1.1 × 109/L, neutrophil-to-lymphocyte ratio > 3.53, fibrinogen > 4 g/L, d-dimer > 0.55 μg/mL, blood urea nitrogen > 7.1 mM, elevated aspartate transaminase, elevated alanine aminotransferase, total bilirubin > 21 μM, and Sequential Organ Failure Assessment (SOFA) score ≥ 2 were identified as risk factors for critical illness. LASSO logistic regression identified the best combination of risk factors as SOFA score, age, dyspnea, and leukocytosis. The Area Under the Receiver-Operator Curve values for the risk factors in predicting critical illness were 0.921 for SOFA score, 0.776 for age, 0.764 for dyspnea, 0.658 for leukocytosis, and 0.960 for the combination of the four risk factors. Conclusions Our findings advocate the use of risk factors SOFA score ≥ 2, age > 60, dyspnea and leukocytosis > 9.5 × 109/L on admission, alone or in combination, to determine the optimal management of the patients and health care resources.
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Cheng, Sijing; Wu, Dingfeng; Li, Jie; Zou, Yifeng; Wan, Yunle; Shen, Lihan; et al. (2020). Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5182737.v1
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AUTHORS (20)
SC
Sijing Cheng
DW
Dingfeng Wu
JL
Jie Li
YZ
Yifeng Zou
YW
Yunle Wan
LS
Lihan Shen
LZ
Lixin Zhu
MS
Mang Shi
LH
Linlin Hou
TX
Tao Xu
NJ
Na Jiao
YL
Yichen Li
YH
Yibo Huang
ZT
Zhipeng Tang
MX
Mingwei Xu
SJ
Shusong Jiang
ML
Maokun Li
GY
Guangjun Yan
PL
Ping Lan
RZ
Ruixin Zhu