Replicated methylation changes associated with eczema herpeticum and allergic response
Posted on 2019-08-24 - 03:52
Abstract Background Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with eczema herpeticum (ADEH+). We will determine how methylation varies in AD individuals with/without EH and associated traits. We modeled differences in genome-wide DNA methylation in whole blood cells from 90 ADEH+, 83 ADEHâ, and 84 non-atopic, healthy control subjects, replicating in 36 ADEH+, 53 ADEHâ, and 55 non-atopic healthy control subjects. We adjusted for cell-type composition in our models and used genome-wide and candidate-gene approaches. Results We replicated one CpG which was significantly differentially methylated by severity, with suggestive replication at four others showing differential methylation by phenotype or severity. Not adjusting for eosinophil content, we identified 490 significantly differentially methylated CpGs (ADEH+ vs healthy controls, genome-wide). Many of these associated with severity measures, especially eosinophil count (431/490 sites). Conclusions We identified a CpG in IL4 associated with serum tIgE levels, supporting a role for Th2 immune mediating mechanisms in AD. Changes in eosinophil level, a measure of disease severity, are associated with methylation changes, providing a potential mechanism for phenotypic changes in immune response-related traits.
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Boorgula, Meher; Taub, Margaret; Rafaels, Nicholas; Daya, Michelle; Campbell, Monica; Chavan, Sameer; et al. (2019). Replicated methylation changes associated with eczema herpeticum and allergic response. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4642790.v1
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AUTHORS (21)
MB
Meher Boorgula
MT
Margaret Taub
NR
Nicholas Rafaels
MD
Michelle Daya
MC
Monica Campbell
SC
Sameer Chavan
AS
Aniket Shetty
CC
Chris Cheadle
SB
Sangjucta Barkataki
JF
Jinshui Fan
GD
Gloria David
TB
Terri Beaty
IR
Ingo Ruczinski
JH
Jon Hanifin
LS
Lynda Schneider
RG
Richard Gallo
AP
Amy Paller
LB
Lisa Beck
DL
Donald Leung
RM
Rasika Mathias