Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
Posted on 2020-04-04 - 03:57
Abstract MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1) were synthesized by Songogashira coupling reaction by using microwave-assisted synthetic technology. The isomers can recognize and stabilize miR-21, with the Λ-isomer showing a stronger binding capacity than the Δ-isomer. Further studies showed that both isomers can be uptaken by MDA-MB-231 cells and enriched in the nucleus. Treatment with the Λ-/Δ-isomer downregulated the expression of miR-21. In a word, the development of chiral ruthenium(II) complexes act as potential inhibitors against tumor cells by recognizing, stabilizing, and regulating the expression of miR-21.
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Feng, Yin; Shu, Jing; Yao, Liangzhong; Lan, Yutao; Ye, Lianbao; Mei, Wenjie; et al. (2020). Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4925139.v1
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AUTHORS (7)
YF
Yin Feng
JS
Jing Shu
LY
Liangzhong Yao
YL
Yutao Lan
LY
Lianbao Ye
WM
Wenjie Mei
YD
Ying Ding