Pubertal timing and breast density in young women: a prospective cohort study
Posted on 2019-11-15 - 05:25
Abstract Background Earlier age at onset of pubertal events and longer intervals between them (tempo) have been associated with increased breast cancer risk. It is unknown whether the timing and tempo of puberty are associated with adult breast density, which could mediate the increased risk. Methods From 1988 to 1997, girls participating in the Dietary Intervention Study in Children (DISC) were clinically assessed annually between ages 8 and 17 years for Tanner stages of breast development (thelarche) and pubic hair (pubarche), and onset of menses (menarche) was self-reported. In 2006–2008, 182 participants then aged 25–29 years had their percent dense breast volume (ÛV) measured by magnetic resonance imaging. Multivariable, linear mixed-effects regression models adjusted for reproductive factors, demographics, and body size were used to evaluate associations of age and tempo of puberty events with ÛV. Results The mean (standard deviation) and range of ÛV were 27.6 (20.5) and 0.2–86.1. Age at thelarche was negatively associated with ÛV (p trend = 0.04), while pubertal tempo between thelarche and menarche was positively associated with ÛV (p trend = 0.007). ÛV was 40% higher in women whose thelarche-to-menarche tempo was 2.9 years or longer (geometric mean (95%CI) = 21.8% (18.2–26.2%)) compared to women whose thelarche-to-menarche tempo was less than 1.6 years (geometric mean (95%CI) = 15.6% (13.9–17.5%)). Conclusions Our results suggest that a slower pubertal tempo, i.e., greater number of months between thelarche and menarche, is associated with higher percent breast density in young women. Future research should examine whether breast density mediates the association between slower tempo and increased breast cancer risk.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Houghton, Lauren; Jung, Seungyoun; Troisi, Rebecca; LeBlanc, Erin; Snetselaar, Linda; Hylton, Nola; et al. (2019). Pubertal timing and breast density in young women: a prospective cohort study. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4740506.v1
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (12)
LH
Lauren Houghton
SJ
Seungyoun Jung
RT
Rebecca Troisi
EL
Erin LeBlanc
LS
Linda Snetselaar
NH
Nola Hylton
CK
Catherine Klifa
LH
Linda Horn
KP
Kenneth Paris
JS
John Shepherd
RH
Robert Hoover
JD
Joanne Dorgan