Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer
Posted on 2020-11-12 - 04:44
Abstract One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA-derived small RNAs [tsRNAs], rRNA-derived small RNAs [rsRNAs], and YRNA-derived small RNAs [ysRNAs]) in human peripheral blood mononuclear cells and develop a molecular signature composed of distinct ts/rs/ysRNAs (TRY-RNA). Our TRY-RNA signature precisely discriminates between control, lung cancer, and pulmonary TB subjects in both the discovery and validation cohorts and outperforms microRNA-based biomarkers, which bears the diagnostic potential for lung cancer screening.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Gu, Wanjun; Shi, Junchao; Liu, Hui; Zhang, Xudong; Zhou, Jin J.; Li, Musheng; et al. (2020). Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5204837.v1
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (22)
WG
Wanjun Gu
JS
Junchao Shi
HL
Hui Liu
XZ
Xudong Zhang
JZ
Jin J. Zhou
ML
Musheng Li
DZ
Dandan Zhou
RL
Rui Li
JL
Jingzhu Lv
GW
Guoxia Wen
SZ
Shanshan Zhu
TQ
Ting Qi
WL
Wei Li
XW
Xiaojing Wang
ZW
Zhaohua Wang
HZ
Hua Zhu
CZ
Changcheng Zhou
KK
Kenneth S. Knox
TW
Ting Wang
QC
Qi Chen