Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer
Posted on 2020-11-12 - 04:44
Abstract One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA-derived small RNAs [tsRNAs], rRNA-derived small RNAs [rsRNAs], and YRNA-derived small RNAs [ysRNAs]) in human peripheral blood mononuclear cells and develop a molecular signature composed of distinct ts/rs/ysRNAs (TRY-RNA). Our TRY-RNA signature precisely discriminates between control, lung cancer, and pulmonary TB subjects in both the discovery and validation cohorts and outperforms microRNA-based biomarkers, which bears the diagnostic potential for lung cancer screening.
CITE THIS COLLECTION
Gu, Wanjun; Shi, Junchao; Liu, Hui; Zhang, Xudong; Zhou, Jin J.; Li, Musheng; et al. (2020): Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5204837.v1
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AUTHORS (22)
WG
Wanjun Gu
JS
Junchao Shi
HL
Hui Liu
XZ
Xudong Zhang
JZ
Jin J. Zhou
ML
Musheng Li
DZ
Dandan Zhou
RL
Rui Li
JL
Jingzhu Lv
GW
Guoxia Wen
SZ
Shanshan Zhu
TQ
Ting Qi
WL
Wei Li
XW
Xiaojing Wang
ZW
Zhaohua Wang
HZ
Hua Zhu
CZ
Changcheng Zhou
KK
Kenneth S. Knox
TW
Ting Wang
QC
Qi Chen