Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer

Posted on 2020-11-12 - 04:44
Abstract One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA-derived small RNAs [tsRNAs], rRNA-derived small RNAs [rsRNAs], and YRNA-derived small RNAs [ysRNAs]) in human peripheral blood mononuclear cells and develop a molecular signature composed of distinct ts/rs/ysRNAs (TRY-RNA). Our TRY-RNA signature precisely discriminates between control, lung cancer, and pulmonary TB subjects in both the discovery and validation cohorts and outperforms microRNA-based biomarkers, which bears the diagnostic potential for lung cancer screening.

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Gu, Wanjun; Shi, Junchao; Liu, Hui; Zhang, Xudong; Zhou, Jin J.; Li, Musheng; et al. (2020): Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5204837.v1
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Molecular Cancer

AUTHORS (22)

Wanjun Gu
Junchao Shi
Hui Liu
Xudong Zhang
Jin J. Zhou
Musheng Li
Dandan Zhou
Rui Li
Jingzhu Lv
Guoxia Wen
Shanshan Zhu
Ting Qi
Wei Li
Xiaojing Wang
Zhaohua Wang
Hua Zhu
Changcheng Zhou
Kenneth S. Knox
Ting Wang
Qi Chen
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