Patterns of olfactory dysfunctions in patients with Parkinson disease
Posted on 2020-07-11 - 16:09
Abstract Background Olfactory dysfunction (OD) is a well-established nonmotor manifestations (NMM) of Parkinson disease (PD) which needs objective assessment for better understanding of the disease pathogenesis. The aim of this work was quantitative and qualitative assessment of olfactory performance in newly diagnosed PD patients. Methods This study was performed on 32 recently diagnosed PD patients and 24 healthy controls subjects (HCS) submitted to unified Parkinson’s disease rating scale–III (UPDRS–III), extended n-butanol Sniffin’ Sticks test (SST) and olfactory bulbs volumetry (OBV). Results There were significant decreases in SST threshold, discrimination, identification, and TDI variables as well as OBV in PD patients compared to HCS. The olfactory performance was negatively correlated with disease duration but had no relation with PD severity as well as motor subtype. Conclusion OD is highly prevalent during the early stages of PD which is both measurable and specific with identification and discrimination impairments to certain odors which makes smell performance testing an important step in PD patients’ evaluation.
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Rashed, Khaled Hussein; Bahnasy, Wafik Said; El-Heneedy, Yasser Abo Elfotoh; El-Seidy, Ehab Ahmed Shawky; Tomoum, Mohamed Osama; Eltomey, Mohamed Adel; et al. (2020). Patterns of olfactory dysfunctions in patients with Parkinson disease. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5056695.v1
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AUTHORS (7)
KR
Khaled Hussein Rashed
WB
Wafik Said Bahnasy
YE
Yasser Abo Elfotoh El-Heneedy
EE
Ehab Ahmed Shawky El-Seidy
MT
Mohamed Osama Tomoum
ME
Mohamed Adel Eltomey
SE
Shereen Ahmed ELAhwal