Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study
Posted on 2020-04-15 - 03:23
Abstract Background Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk. Methods A retrospective matched case-control study of patients over 50 with rheumatoid arthritis (486 dementia cases and 641 controls) who were identified from electronic health records in the UK, Spain, Denmark and the Netherlands. Conditional logistic regression models were fitted to estimate the risk of dementia. Results Prior methotrexate use was associated with a lower risk of dementia (OR 0.71, 95% CI 0.52–0.98). Furthermore, methotrexate use with therapy longer than 4 years had the lowest risk of dementia (odds ratio 0.37, 95% CI 0.17–0.79). Sulfasalazine use was not associated with dementia (odds ratio 0.88, 95% CI 0.57–1.37). Conclusions Further studies are still required to clarify the relationship between prior methotrexate use and duration as well as biological treatments with dementia risk.
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Newby, Danielle; Prieto-Alhambra, Daniel; Duarte-Salles, Talita; Ansell, David; Pedersen, Lars; van der Lei, Johan; et al. (2020). Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4929765.v2
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AUTHORS (18)
DN
Danielle Newby
DP
Daniel Prieto-Alhambra
TD
Talita Duarte-Salles
DA
David Ansell
LP
Lars Pedersen
Jv
Johan van der Lei
MM
Mees Mosseveld
PR
Peter Rijnbeek
GJ
Glen James
MA
Myriam Alexander
PE
Peter Egger
JP
Jana Podhorna
RS
Robert Stewart
GP
Gayan Perera
PA
Paul Avillach
SG
Solène Grosdidier
SL
Simon Lovestone
AN
Alejo J. Nevado-Holgado