MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties
Posted on 2016-02-17 - 05:00
Abstract Background Medulloblastoma is the most common malignant brain tumor in children and can be divided in different molecular subgroups. Patients whose tumor is classified as a Group 3 tumor have a dismal prognosis. However only very few tumor models are available for this subgroup. Methods We established a robust orthotopic xenograft model with a cell line derived from the malignant pleural effusions of a child suffering from a Group 3 medulloblastoma. Results Besides classical characteristics of this tumor subgroup, the cells display cancer stem cell characteristics including neurosphere formation, multilineage differentiation, CD133/CD15 expression, high ALDH-activity and high tumorigenicity in immunocompromised mice with xenografts exactly recapitulating the original tumor architecture. Conclusions This model using unmanipulated, human medulloblastoma cells will enable translational research, specifically focused on Group 3 medulloblastoma.
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Dietl, Sebastian; Schwinn, Stefanie; Dietl, Susanne; Riedel, Simone; Deinlein, Frank; Rutkowski, Stefan; et al. (2016). MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3624113.v1
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AUTHORS (20)
SD
Sebastian Dietl
SS
Stefanie Schwinn
SD
Susanne Dietl
SR
Simone Riedel
FD
Frank Deinlein
SR
Stefan Rutkowski
Av
Andre von Bueren
JK
JĂźrgen Krauss
TS
Tilmann Schweitzer
GV
Giles Vince
DP
Daniel Picard
ME
Matthias Eyrich
AR
Andreas Rosenwald
VR
Vijay Ramaswamy
MT
Michael Taylor
MR
Marc Remke
CM
Camelia Monoranu
AB
Andreas Beilhack
PS
Paul Schlegel
MW
Matthias WĂślfl