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MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells

Posted on 2019-10-23 - 08:25
Abstract Background Cancer/testis antigens (CTAs) are a special type of tumor antigen and are believed to act as potential targets for cancer immunotherapy. Methods In this study, we first screened a rational CTA MAGE-A1 for lung adenocarcinoma (LUAD) and explored the detailed characteristics of MAGE-A1 in LUAD development through a series of phenotypic experiments. Then, we developed a novel MAGE-A1-CAR-T cell (mCART) using lentiviral vector based on our previous MAGE-A1-scFv. The anti-tumor effects of this mCART were finally investigated in vitro and in vivo. Results The results showed striking malignant behaviors of MAGE-A1 in LUAD development, which further validated the rationality of MAGE-A1 as an appropriate target for LUAD treatment. Then, the innovative mCART was successfully constructed, and mCART displayed encouraging tumor-inhibitory efficacy in LUAD cells and xenografts. Conclusions Taken together, our data suggest that MAGE-A1 is a promising candidate marker for LUAD therapy and the MAGE-A1-specific CAR-T cell immunotherapy may be an effective strategy for the treatment of MAGE-A1-positive LUAD.

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Journal of Hematology & Oncology

AUTHORS (16)

Yuan Mao
Weifei Fan
Hao Hu
Louqian Zhang
Jerod Michel
Yaqin Wu
Jun Wang
Lizhou Jia
Xiaojun Tang
Li Xu
Yan Chen
Jin Zhu
Zhenqing Feng
Lin Xu
Rong Yin
Qi Tang
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