Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial
Posted on 2021-03-05 - 04:36
Abstract Background DNA methylation age (mAge), a methylation biomarker for the aging process, might serve as a more accurate predictor of morbidity and aging status than chronological age. We evaluated the role of multiple factors, including fat deposition, cardiometabolic risk factors and lifestyle weight-loss intervention, on the deviation of mAge from chronological age (mAge deviation) or 18-month change in mAge (∆mAge). In this sub-study of the CENTRAL magnetic resonance imaging weight-loss trial, we evaluated mAge by a validated 240-CpG-based prediction formula at baseline and after 18-month intervention of either low fat (LF) or mediterranean/low carbohydrate (MED/LC) diets. Results Among 120 CENTRAL participants with abdominal obesity or dyslipidemia, mAge (mean ± SD: 60.3 ± 7.5 years) was higher than the chronological age (48.6 ± 9.3 years) but strongly correlated (r = 0.93; p = 3.1 × 10–53). Participants in the lowest tertile of mAge deviation from their chronological age had significantly lower waist-circumference, visceral adipose tissue, intrahepatic fat (IHF) content, fasting-glucose and HOMA-IR, as compared with participants in the highest sex-specific residual tertile (p < 0.05 for all). IHF% remained associated with greater mAge deviation after further adjustments (β = 0.23; p = 0.02). After 18-month weight-loss lifestyle intervention, mAge remained significantly correlated with chronological age (r = 0.94, p = 1.5 × 10–55). mAging occurred, with no difference between lifestyle intervention groups (∆ = 0.9 ± 1.9 years in MED/LC vs. ∆ = 1.3 ± 1.9 years in LF; p = 0.2); however, we observed a mAging attenuation in successful weight losers (> 5% weight loss) vs. weight-loss failures ( ∆ = 0.6 years vs. ∆ = 1.1 years; p = 0.04), and in participants who completed the trial with healthy liver fat content (< 5% IHF) vs. participants with fatty liver (∆ = 0.6 years vs. ∆ = 1.8 years; p = 0.003). Overall, 18 months of weight-loss lifestyle intervention attenuated the mAging of the men, mainly the older, by 7.1 months than the expected (p < 0.05). Conclusions Lifestyle weight-loss intervention may attenuate mAging. Deviation of mAge from chronological age might be related to body fat distribution and glycemic control and could indicate biological age, health status and the risk for premature cardiometabolic diseases. Trial registration: ClinicalTrials.gov NCT01530724. Registered 10 February 2012, https://clinicaltrials.gov/ct2/show/study/NCT01530724 .
CITE THIS COLLECTION
Yaskolka Meir, Anat; Keller, Maria; Bernhart, Stephan H.; Rinott, Ehud; Tsaban, Gal; Zelicha, Hila; et al. (2021). Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5328052.v1
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication

AUTHORS (20)
AY
Anat Yaskolka Meir
MK
Maria Keller
SB
Stephan H. Bernhart
ER
Ehud Rinott
GT
Gal Tsaban
HZ
Hila Zelicha
AK
Alon Kaplan
DS
Dan Schwarzfuchs
IS
Ilan Shelef
YG
Yftach Gepner
JL
Jun Li
YL
Yifei Lin
MB
Matthias Blüher
UC
Uta Ceglarek
MS
Michael Stumvoll
PS
Peter F. Stadler
MS
Meir J. Stampfer
PK
Peter Kovacs
LL
Liming Liang
IS
Iris Shai