Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
Posted on 2020-05-28 - 03:36
Abstract Background Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. Case presentation We describe the infection with a GI.2 strain, “Bremerhaven-17”, in captive mountain hares (Lepus timidus) in a zoo facility in Germany. Postmortem examination revealed RHD-like lesions including necrotizing hepatitis. RT-qPCR and AG-ELISA confirmed presence of GI.2. Recombination and phylogenetic analysis grouped the identified strain with other GI.2 strains, sharing nucleotide identity of 91–99%. Conclusion Our findings confirm that mountain hares are susceptible to GI.2 infection, due to a past recombination event facilitating virus spillover from sympatric rabbits.
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Buehler, Melanie; Jesse, Sonja T.; Kueck, Heike; Lange, Bastian; Koenig, Patricia; Jo, Wendy K.; et al. (2020). Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4996043.v1
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AUTHORS (8)
MB
Melanie Buehler
SJ
Sonja T. Jesse
HK
Heike Kueck
BL
Bastian Lange
PK
Patricia Koenig
WJ
Wendy K. Jo
AO
Albert Osterhaus
AB
Andreas Beineke