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International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Posted on 2015-08-28 - 05:00
Abstract Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals. The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures. Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements. The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.

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AUTHORS (22)

Kaspar Matiasek
MartĂ­ Pumarola i Batlle
Marco Rosati
Francisco FernĂĄndez-Flores
Andrea Fischer
Eva Wagner
Mette Berendt
Sofie Bhatti
Luisa De Risio
Robyn Farquhar
Sam Long
Karen MuĂąana
Edward Patterson
Akos Pakozdy
Jacques Penderis
Simon Platt
Michael Podell
Heidrun Potschka
Clare Rusbridge
Veronika Stein
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