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International Analgesia, Sedation, and Delirium Practices: a prospective cohort study

Posted on 2019-04-24 - 05:00
Abstract Background While understanding of critical illness and delirium continue to evolve, the impact on clinical practice is often unknown and delayed. Our purpose was to provide insight into practice changes by characterizing analgesia and sedation usage and occurrence of delirium in different years and international regions. Methods We performed a retrospective analysis of two multicenter, international, prospective cohort studies. Mechanically ventilated adults were followed for up to 28 days in 2010 and 2016. Proportion of days utilizing sedation, analgesia, and performance of a spontaneous awakening trial (SAT), and occurrence of delirium were described for each year and region and compared between years. Results A total of 14,281 patients from 6 international regions were analyzed. Proportion of days utilizing analgesia and sedation increased from 2010 to 2016 (p < 0.001 for each). Benzodiazepine use decreased in every region but remained the most common sedative in Africa, Asia, and Latin America. Performance of SATs increased overall, driven mostly by the US/Canada region (24 to 35% of days with sedation, p < 0.001). Any delirium during admission increased from 7 to 8% of patients overall and doubled in the US/Canada region (17 to 36%, p < 0.001). Conclusions Analgesia and sedation practices varied widely across international regions and significantly changed over time. Opportunities for improvement in care include increasing delirium monitoring, performing SATs, and decreasing use of sedation, particularly benzodiazepines.

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Journal of Intensive Care

AUTHORS (22)

  • Gary Owen
    Joanna Stollings
    Shayan Rakhit
    Li Wang
    Chang Yu
    Morgan Hosay
    James Stewart
    Fernando Frutos-Vivar
    Oscar Peñuelas
    Andres Esteban
    Antonio Anzueto
    Konstantinos Raymondos
    Fernando Rios
    Arnaud Thille
    Marco González
    Bin Du
    Salvatore Maggiore
    Dimitrios Matamis
    Fekri Abroug
    Pravin Amin
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