High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study
Posted on 2019-08-02 - 07:07
Abstract Background The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid levels on mortality in peritoneal dialysis patients. Methods Data on 9405 peritoneal dialysis patients from the Zhejiang Renal Data system were retrospectively analyzed. All demographic and laboratory data were recorded at baseline. The study cohort was divided into quintiles according to baseline uric acid level (mg/dL): Q1 (< 6.06), Q2 (6.06–6.67), Q3 (6.68–7.27) (reference), Q4 (7.28–8.03), and Q5 (≥8.04). Hazards ratio (HR) of all-cause and cardiovascular mortality was calculated. Results Mean serum uric acid was 7.07 ± 1.25 mg/dL. During a median follow-up of 29.4 (range, 3.0 to 115.4) months, 1226 (13.0%) patients died, of which 515 (5.5%) died of cardiovascular events. The Kaplan-Meier survival curves showed that patients in the middle uric acid quintile (Q3: 6.68–7.27) exhibited the highest patient and cardiovascular survival rates (log-rank test P < 0.05). Multivariate Cox regression analysis showed that, using Q3 as the reference, in the fully adjusted model, a higher uric acid level (Q4: 7.28–8.03, and Q5: ≥8.04) was significantly associated with higher all-cause mortality (Model 3; Q4: HR, 1.335, 95% CI, 1.073 to 1.662, P = 0.009; Q5: HR, 1.482, 95% CI, 1.187 to 1.849, P = 0.001), but not with cardiovascular mortality. The adverse effect of higher uric acid level (≥7.28 mg/dL) on all-cause mortality was more prominent in groups such as male, hypoalbuminemia, normal weight, non-diabetes mellitus at baseline rather than in their counterparts respectively. Conclusions A higher uric acid level was an independent risk factor for all-cause mortality in peritoneal dialysis patients.
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Xiang, Shilong; Zhang, Xiaohui; Xie, Xishao; Wang, Junni; Zhou, Qin; Chen, Zhimin; et al. (2019). High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4604873.v1
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AUTHORS (10)
SX
Shilong Xiang
XZ
Xiaohui Zhang
XX
Xishao Xie
JW
Junni Wang
QZ
Qin Zhou
ZC
Zhimin Chen
YW
Yaomin Wang
GL
Guangjun Liu
FH
Fei Han
JC
Jianghua Chen