Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection
Posted on 2020-04-03 - 03:49
Abstract Hepatitis E virus (HEV) as an emerging zoonotic pathogen causes a major public health issue. Transmission from domestic, wildlife and zoo animals to human has been widely reported. Whether pets also serve as reservoirs remains an intriguing question. In this study, we found the sero-positive rates of HEV-specific antibodies in pet dogs, cats and horses of 18.52% (30/162), 14.89% (7/47) and 18.18% (4/22) in the Netherlands. Although HEV viral RNA was not detected in these animals, we have demonstrated that dog liver cells are susceptible to HEV infection in vitro. These results call more attention to address the potential role of pets in the zoonotic transmission of HEV.
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Li, Yunlong; Qu, Changbo; Spee, Bart; Zhang, Ruyi; Penning, Louis C.; de Man, Robert A.; et al. (2020). Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4920981.v1
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AUTHORS (9)
YL
Yunlong Li
CQ
Changbo Qu
BS
Bart Spee
RZ
Ruyi Zhang
LP
Louis C. Penning
Rd
Robert A. de Man
MP
Maikel P. Peppelenbosch
HF
Hille Fieten
QP
Qiuwei Pan