Hemozoin “knobs” in Opisthorchis felineus infected liver
Posted on 2015-09-17 - 05:00
Abstract Background Hemozoin is the pigment produced by some blood-feeding parasites. It demonstrates high diagnostic and therapeutic potential. In this work the formation of co-called hemozoin “knobs” – the bile duct ectasia filled up by hemozoin pigment - in Opisthorhis felineus infected hamster liver has been observed. Methods The O. felineus infected liver was examined by histological analysis and magnetic resonance imaging (MRI). The pigment hemozoin was identified by Fourier transform infrared spectroscopy and high resolution electrospray ionization mass spectrometry analysis. Hemozoin crystals were characterised by high resolution transmission electron microscopy. Results Hemozoin crystals produced by O. felineus have average length 403 nm and the length-to-width ratio equals 2.0. The regurgitation of hemozoin from parasitic fluke during infection leads to formation of bile duct ectasia. The active release of hemozoin from O. felineus during in vitro incubation has also been evidenced. It has been shown that the hemozoin knobs can be detected by magnetic resonance imaging. Conclusions In the paper for the first time the characterisation of hemozoin pigment extracted from liver fluke O. felineus has been conducted. The role of hemozoin in the modification of immune response by opisthorchiasis is assumed.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Pershina, Alexandra; Saltykova, Irina; Ivanov, Vladimir; Perina, Ekaterina; Demin, Alexander; Shevelev, Oleg; et al. (2016). Hemozoin “knobs” in Opisthorchis felineus infected liver. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3643838.v1
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (13)
AP
Alexandra Pershina
IS
Irina Saltykova
VI
Vladimir Ivanov
EP
Ekaterina Perina
AD
Alexander Demin
OS
Oleg Shevelev
IB
Irina Buzueva
AG
Anton Gutakovskii
SV
Sergey Vtorushin
IG
Ilya Ganebnykh
VK
Victor Krasnov
AS
Alexey Sazonov
LO
Ludmila Ogorodova