First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study
Posted on 2021-01-10 - 04:16
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. Methods National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. Results Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53–80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia and thrombocytopenia within ±24-h of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were independently associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. Conclusions Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were independent factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher in males after surviving the first week.
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Holler, Jon Gitz; Eriksson, Robert; Jensen, Tomas Østergaard; van Wijhe, Maarten; Fischer, Thea Kølsen; Søgaard, Ole Schmeltz; et al. (2021). First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5263239.v1
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AUTHORS (17)
JH
Jon Gitz Holler
RE
Robert Eriksson
TJ
Tomas Østergaard Jensen
Mv
Maarten van Wijhe
TF
Thea Kølsen Fischer
OS
Ole Schmeltz Søgaard
SI
Simone Bastrup Israelsen
RM
Rajesh Mohey
TF
Thilde Fabricius
FJ
Frederik Jøhnk
LW
Lothar Wiese
SJ
Stine Johnsen
CS
Christian Søborg
HN
Henrik Nielsen
OK
Ole Kirk
BM
Birgitte Lindegaard Madsen
ZH
Zitta Barrella Harboe