Essential tremor: what is beyond the oscillatory monosymptomatic illness?
Posted on 2020-07-07 - 05:06
Abstract Background Essential tremor (ET) is now considered as a slowly progressive neurodegenerative disorder with a variety of motor and non-motor manifestations. The objectives of this work were to study the existence of cognitive, mood, olfactory, and balance dysfunctions in ET patients and their relation to tremor severity as well as patients’ activity of daily livings. Methods This study was performed on 36 ET patients and 24 healthy controls subjects (HCS) submitted to The Essential Tremor Rating Assessment Scale (TETRAS), advanced activity of daily living scale (AADLs), Montreal cognitive assessment scale (MoCA), Montgomery–Åsberg Depression Rating Scale (MADRS), auditory mismatch negativity (MMN), Sniffin’ Sticks test (SST), computerized dynamic posturography (CDP), and brain MRI diffusion tensor tractography (DTT). Results ET patients showed significant decrease in AADLs, MoCA, SST (threshold, identification, and discrimination subscales) as well as visual and vestibular ratios of CDP compared to HCS. Auditory MMN showed significant reduction in the amplitude and prolongation of latencies while corticospinal tracts, thalamo-cortical connectivity, and middle cerebellar peduncles DTT revealed reduced fractional anisotropy in ET patients with normal tracts densities. Conclusion ET patients exhibit a wide variety of non-motor manifestations including cognitive impairment, depressive symptoms, hyposmia, and increased risk of falls with consecutive reduced activity of daily living beyond the deleterious effects of the kinetic tremor.
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Elhassanien, Mahmoud Ebrahim Mostafa; Rashed, Khaled Hussein; Bahnasy, Wafik Said; El-Heneedy, Yasser Abo Elfotoh; El-Seidy, Ehab Ahmed Shawky; Tomoum, Mohamed Osama; et al. (2020). Essential tremor: what is beyond the oscillatory monosymptomatic illness?. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5051370.v1
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AUTHORS (10)
ME
Mahmoud Ebrahim Mostafa Elhassanien
KR
Khaled Hussein Rashed
WB
Wafik Said Bahnasy
YE
Yasser Abo Elfotoh El-Heneedy
EE
Ehab Ahmed Shawky El-Seidy
MT
Mohamed Osama Tomoum
KR
Kareem Mohammed Ramadan
MK
Mona Ahmed Kotait
RA
Reham Abdel Rahman Amer
SE
Shereen Ahmed ELAhwal