Dynamic observation and analysis of metabolic response to moxibustion stimulation on ethanol-induced gastric mucosal lesions (GML) rats
Posted on 2019-10-16 - 04:02
Abstract Background Gastric mucosal lesion (GML) is the initiating pathological process in many refractory gastric diseases. And moxibustion is an increasingly popular alternative therapy that prevents and treats diseases. However, there are few published reports about developing pathology of GML and therapeutic mechanism of moxibustion treatment on GML. In this study, we investigated pathology of GML and therapeutic mechanism of moxibustion treatment on GML. Methods The male Sprague-Dawley (SD) rats were induced by intragastric administration of 75% ethanol after fasting for 24 h and treated by moxibustion at Zusanli (ST36) and Liangmen (ST21) for 1 day, 4 days or 7 days. Then we applied 1H NMR-based metabolomics to dynamic analysis of metabolic profiles in biological samples (stomach, cerebral cortex and medulla). And the conventional histopathological examinations as well as metabolic pathways assays were also performed. Results Moxibustion intervention showed a beneficial effect on GML by modulating comprehensive metabolic alterations caused by GML, including energy metabolism, membrane metabolism, cellular active and neurotransmitters function. Conclusions Moxibustion can effectively treat gastric mucosal damage and effectively regulate the concentration of some related differential metabolites to maintain the stability of the metabolic pathway.
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Zhang, Yuan; Huang, Miao-sen; Liu, Cai-chun; Lian, Lin-yu; Shen, Jia-cheng; He, Qi-da; et al. (2019). Dynamic observation and analysis of metabolic response to moxibustion stimulation on ethanol-induced gastric mucosal lesions (GML) rats. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4699829.v1
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AUTHORS (10)
YZ
Yuan Zhang
MH
Miao-sen Huang
CL
Cai-chun Liu
LL
Lin-yu Lian
JS
Jia-cheng Shen
QH
Qi-da He
YW
Ying-jie Wang
LZ
Long-bin Zhang
ML
Mi Liu
ZY
Zong-bao Yang