Dok-3 deficient mice display different immune clustering and Tim-3 expression
Posted on 2019-07-28 - 03:44
Abstract Background Dok-3 has been shown to play an important role in immune system. Tim-3 also has been recognized as an important immune regulator which involves in many diseases. The relationship of them is still unclear. Methods We detected the expression of Tim-3 on spleen immune cells from Dok-3 deficient mice and control mice by flow cytometry. Results In this article, we found that Dok-3−/− mice display almost entirely different immune clustering characteristics compared with wild type 129 mice. The CD4 T cells and CD8 T cells decreased and DC cells, macrophages, MDSCs increased when the Dok-3 gene knocked-out. The Tim-3 expression on CD4 T cells, CD8 T cells, NK cells, DC cells increased when the Dok-3 gene knocked-out. The macrophages and MDSCs just display the opposite results. Conclusions Although Dok-3−/− mice display different immune clustering and Tim-3 expression, the mechanism still needs further study.
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Yan, Wenjiang; Tian, Yijia; Sun, Peng; Yang, Jingjing; Li, Na; Sun, Yuanyuan; et al. (2019). Dok-3 deficient mice display different immune clustering and Tim-3 expression. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4591793.v1
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AUTHORS (8)
WY
Wenjiang Yan
YT
Yijia Tian
PS
Peng Sun
JY
Jingjing Yang
NL
Na Li
YS
Yuanyuan Sun
SW
Shuangxi Wang
CZ
Cheng Zhang