Discordant transmission of bacteria and viruses from mothers to babies at birth
Posted on 2019-12-11 - 10:44
Abstract Background The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood. To better understand how the maternal gut microbiome influences acquisition of the infant gut microbiome, we studied the early life bacterial microbiomes and viromes of 28 infant twin pairs and their mothers. Results Infant bacterial and viral communities more closely resemble those of their related co-twin than unrelated infants. We found that 63% of an infant’s bacterial microbiome can be traced to their mother’s gut microbiota. In contrast, only 15% of their viral communities are acquired from their mother. Delivery route did not determine how much of the bacterial microbiome or virome was shared from mother to infant. However, bacteria-bacteriophage interactions were altered by delivery route. Conclusions The maternal gut microbiome significantly influences infant gut microbiome acquisition. Vertical transmission of the bacterial microbiome is substantially higher compared to vertical transmission of the virome. However, the degree of similarity between the maternal and infant gut bacterial microbiome and virome did not vary by delivery route. The greater similarity of the bacterial microbiome and virome between twin pairs than unrelated twins may reflect a shared environmental exposure. Thus, differences of the inter-generation transmissibility at birth between the major kingdoms of microbes indicate that the foundation of these microbial communities are shaped by different rules. Video Abstract
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Maqsood, Rabia; Rodgers, Rachel; Rodriguez, Cynthia; Handley, Scott; Ndao, I.; Tarr, Phillip; et al. (2019). Discordant transmission of bacteria and viruses from mothers to babies at birth. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4777460.v1
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AUTHORS (9)
RM
Rabia Maqsood
RR
Rachel Rodgers
CR
Cynthia Rodriguez
SH
Scott Handley
IN
I. Ndao
PT
Phillip Tarr
BW
Barbara Warner
EL
Efrem Lim
LH
Lori Holtz