Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific oyster mortality syndrome
Posted on 2020-01-21 - 05:12
Abstract Background As a major threat to the oyster industry, Pacific Oyster Mortality Syndrome (POMS) is a polymicrobial disease affecting the main oyster species farmed across the world. POMS affects oyster juveniles and became panzootic this last decade, but POMS resistance in some oyster genotypes has emerged. While we know some genetic loci associated with resistance, the underlying mechanisms remained uncharacterized. So, we developed a comparative transcriptomic approach using basal gene expression profiles between different oyster biparental families with contrasted phenotypes when confronted to POMS (resistant or susceptible). Results We showed that POMS resistant oysters show differential expression of genes involved in stress responses, protein modifications, maintenance of DNA integrity and repair, and immune and antiviral pathways. We found similarities and clear differences among different molecular pathways in the different resistant families. These results suggest that the resistance process is polygenic and partially varies according to the oyster genotype. Conclusions We found differences in basal expression levels of genes related to TLR-NFκB, JAK-STAT and STING-RLR pathways. These differences could explain the best antiviral response, as well as the robustness of resistant oysters when confronted to POMS. As some of these genes represent valuable candidates for selective breeding, we propose future studies should further examine their function.
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Lorgeril, Julien; Petton, Bruno; Lucasson, Aude; Perez, Valérie; Stenger, Pierre-Louis; Dégremont, Lionel; et al. (2020). Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific oyster mortality syndrome. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4823850.v1
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AUTHORS (15)
JL
Julien Lorgeril
BP
Bruno Petton
AL
Aude Lucasson
VP
Valérie Perez
PS
Pierre-Louis Stenger
LD
Lionel Dégremont
CM
Caroline Montagnani
JE
Jean-Michel Escoubas
PH
Philippe Haffner
JA
Jean-François Allienne
ML
Marc Leroy
FL
Franck Lagarde
JV
Jérémie Vidal-Dupiol
YG
Yannick Gueguen
GM
Guillaume Mitta