Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
Posted on 2021-12-05 - 04:16
Abstract Background This study seeks to understand better the mechanisms underlying the increased risk of caries in HIV-infected school-aged Nigerian children by examining the relationship between the plaque microbiome and perinatal HIV infection and exposure. We also seek to investigate how perinatal HIV infection and exposure impact tooth-specific microbiomes' role on caries disease progression. Methods The participants in this study were children aged 4 to 11 years recruited from the University of Benin Teaching Hospital (UBTH), Nigeria, between May to November 2019. Overall, 568 children were enrolled in three groups: 189 HIV-infected (HI), 189 HIV-exposed but uninfected (HEU) and 190 HIV-unexposed and uninfected (HUU) as controls at visit 1 with a 2.99% and 4.90% attrition rate at visit 2 and visit 3 respectively. Data were obtained with standardized questionnaires. Blood samples were collected for HIV, HBV and HCV screening; CD4, CD8 and full blood count analysis; and plasma samples stored for future investigations; oral samples including saliva, buccal swabs, oropharyngeal swab, tongue swab, dental plaque were collected aseptically from participants at different study visits. Conclusions Results from the study will provide critical information on how HIV exposure, infection, and treatment, influence the oral microbiome and caries susceptibility in children. By determining the effect on community taxonomic structure and gene expression of dental microbiomes, we will elucidate mechanisms that potentially create a predisposition for developing dental caries. As future plans, the relationship between respiratory tract infections, immune and inflammatory markers with dental caries in perinatal HIV infection and exposure will be investigated.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Coker, Modupe O.; Akhigbe, Paul; Osagie, Esosa; Idemudia, Nosakhare L.; Igedegbe, Oghenero; Chukwumah, Nneka; et al. (2021). Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5737559.v1
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (13)
MC
Modupe O. Coker
PA
Paul Akhigbe
EO
Esosa Osagie
NI
Nosakhare L. Idemudia
OI
Oghenero Igedegbe
NC
Nneka Chukwumah
RA
Ruxton Adebiyi
AM
Allison E. Mann
LO
Lauren M. O’Connell
OO
Ozo Obuekwe
AO
Augustine Omoigberale
MC
Manhattan E. Charurat
VR
Vincent P. Richards