Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days
Posted on 2020-07-09 - 05:26
Abstract Background A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support the efficacy of this target Cmin has not been obtained. Even though the recommended high Cmin of teicoplanin was associated with better clinical outcome, reaching the target concentration is challenging. Methods Pharmacokinetics and adverse events were evaluated in all eligible patients. For clinical efficacy, patients who had bacteremia/complicated MRSA infections were analyzed. The primary endpoint for clinical efficacy was an early clinical response at 72–96 h after the start of therapy. Five dosed of 12 mg/kg or 10 mg/kg was administered as an enhanced or conventional high loading dose regimen, respectively. The Cmin was obtained at 72 h after the first dose. Results Overall, 512 patients were eligible, and 76 patients were analyzed for treatment efficacy. The proportion of patients achieving the target Cmin range (20–40 μg/mL) by the enhanced regimen was significantly higher than for the conventional regimen (75.2% versus 41.0%, p < 0.001). In multivariate analysis, Cmin ≥ 20 μg/mL was an independent factor for an early clinical response (odds ratio 3.95, 95% confidence interval 1.25–12.53). There was no significant difference in the occurrence of adverse events between patients who did or did not achieve a Cmin ≥ 20 μg/mL. Conclusion A target Cmin ≥ 20 μg/mL might improve early clinical responses during the treatment of difficult MRSA infections using 12 mg/kg teicoplanin for five doses within the initial 3 days.
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Ueda, Takashi; Takesue, Yoshio; Nakajima, Kazuhiko; Ichiki, Kaoru; Ishikawa, Kaori; Takai, Yoshiko; et al. (2020). Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5054119.v1
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AUTHORS (15)
TU
Takashi Ueda
YT
Yoshio Takesue
KN
Kazuhiko Nakajima
KI
Kaoru Ichiki
KI
Kaori Ishikawa
YT
Yoshiko Takai
KY
Kumiko Yamada
TT
Toshie Tsuchida
NO
Naruhito Otani
YT
Yoshiko Takahashi
MI
Mika Ishihara
ST
Shingo Takubo
HI
Hiroki Ikeuchi
MU
Motoi Uchino
TK
Takeshi Kimura