Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas
Posted on 2020-08-07 - 03:50
Abstract Background Immunotherapies targeting glioblastoma (GBM) have led to significant improvements in patient outcomes. TOX is closely associated with the immune environment surrounding tumors, but its role in gliomas is not fully understood. Methods Using data from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), we analyzed the transcriptomes of 1691 WHO grade I-IV human glioma samples. The R language was used to perform most of the statistical analyses. Somatic mutations and somatic copy number variation (CNV) were analyzed using GISTIC 2.0. Results TOX was down-regulated in malignant gliomas compared to low grade gliomas, and upregulated in the proneural and IDH mutant subtypes of GBM. TOXlow tumours are associated with the loss of PTEN and amplification of EGFR, while TOXhigh tumours harbor frequent mutations in IDH1 (91%). TOX was highly expressed in leading edge regions of tumours. Gene ontology and pathway analyses demonstrated that TOX was enriched in multiple immune related processes including lymphocyte migration in GBM. Finally, TOX had a negative association with the infiltration of several immune cell types in the tumour microenvironment. Conclusion TOX has the potential to be a new prognostic marker for GBM.
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Zhang, Hao; Fan, Fan; Yu, Yuanqiang; Wang, Zeyu; Liu, Fangkun; Dai, Ziyu; et al. (2020). Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5085079.v1
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AUTHORS (9)
HZ
Hao Zhang
FF
Fan Fan
YY
Yuanqiang Yu
ZW
Zeyu Wang
FL
Fangkun Liu
ZD
Ziyu Dai
LZ
Liyang Zhang
ZL
Zhixiong Liu
QC
Quan Cheng