Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach
Posted on 2020-07-30 - 06:22
Abstract Background Gastric cancer develops even in Helicobacter pylori(H. pylori)-uninfected patients and its typical histological feature is signet ring cell carcinoma (SRCC) within the mucosal layer. However, the biological characteristics of SRCC remain unclear. We aimed to clarify the pathological and genetic features of SRCC in H. pylori-uninfected patients. Methods Seventeen H. pylori-uninfected patients with mucosal SRCCs were enrolled and their clinicopathological characteristics were compared with those of H. pylori-infected patients with mucosal SRCCs. Seven SRCCs without H. pylori-infected, including two invasive SRCCs, and seven H. pylori-infected SRCCs were subjected to a genetic analysis using next-generation sequencing. Results H. pylori-uninfected patients with mucosal SRCCs revealed male dominancy and a significantly higher prevalence of smokers among them as compared with the H. pylori-infected patients with SRCC. A CDH1 mutation (frame shift indel) was detected in one H. pylori-uninfected cancer not only in the mucosal SRCC but also in the invasive portion. A TP53 mutation was detected in one SRCC without H. pylori-infected. In the control group, ARID1A and TP53 mutations were detected in one SRCC each. The C to A mutation, which is a characteristic smoking-induced mutation, was not found in any of the samples. Conclusions Some SRCCs in H. pylori-uninfected patients may have a malignant potential similar to that of SRCCs in H. pylori-infected patients. Smoking may not be the main carcinogenic factor for the development of SRCCs among the H. pylori-uninfected patients.
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Kiso, Mariko; Urabe, Yuji; Ito, Masanori; Masuda, Kazuhiko; Boda, Tomoyuki; Kotachi, Takahiro; et al. (2020). Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5077514.v1
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AUTHORS (14)
MK
Mariko Kiso
YU
Yuji Urabe
MI
Masanori Ito
KM
Kazuhiko Masuda
TB
Tomoyuki Boda
TK
Takahiro Kotachi
KH
Kosaku Hata
NY
Naoki Yorita
NN
Naoko Nagasaki
MA
Madina Abduwali
YH
Yuich Hiyama
SO
Shiro Oka
ST
Shinji Tanaka
KC
Kazuaki Chayama