An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors
Posted on 2021-12-18 - 04:17
Abstract Metformin and weight loss relationships with epigenetic age measures—biological aging biomarkers—remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese breast cancer survivors (N = 192) assigned to metformin, placebo, weight loss with metformin, or weight loss with placebo interventions for 6 months. Epigenetic age was correlated with chronological age (r = 0.20–0.86; P < 0.005). However, no significant epigenetic aging associations were observed by intervention arms. Consistent with published reports in non-cancer patients, 6 months of metformin therapy may be inadequate to observe expected epigenetic age deceleration. Longer duration studies are needed to better characterize these relationships. Trial Registration: Registry Name: ClincialTrials.Gov. Registration Number: NCT01302379. Date of Registration: February 2011. URL: https://clinicaltrials.gov/ct2/show/NCT01302379
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Nwanaji-Enwerem, Jamaji C.; Chung, Felicia Fei-Lei; Van der Laan, Lars; Novoloaca, Alexei; Cuenin, Cyrille; Johansson, Harriet; et al. (2021). An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5757247.v1
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AUTHORS (13)
JN
Jamaji C. Nwanaji-Enwerem
FC
Felicia Fei-Lei Chung
LV
Lars Van der Laan
AN
Alexei Novoloaca
CC
Cyrille Cuenin
HJ
Harriet Johansson
BB
Bernardo Bonanni
AH
Alan E. Hubbard
MS
Martyn T. Smith
SH
Sheri J. Hartman
AC
Andres Cardenas
DS
Dorothy D. Sears
ZH
Zdenko Herceg