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A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

Posted on 2022-07-07 - 06:43
Abstract The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.

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Journal of Nanobiotechnology

AUTHORS (24)

  • Li-Xing Yang
    Yu-Cheng Liu
    Chang-Hui Cho
    Yi-Rou Chen
    Chan-Shan Yang
    Yin-Lin Lu
    Zhiming Zhang
    Yi-Tseng Tsai
    Yu-Cheng Chin
    Jiashing Yu
    Hsiu-Min Pan
    Wei-Rou Jiang
    Zi-Chun Chia
    Wei-Shiang Huang
    Yu-Lin Chiu
    Chun-Kai Sun
    Yu-Ting Huang
    Li-Ming Chen
    Ken-Tsung Wong
    Han-Min Huang
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