A unified encyclopedia of human functional DNA elements through fully automated annotation of 164 human cell types
Posted on 2019-08-29 - 04:55
Abstract Semi-automated genome annotation methods such as Segway take as input a set of genome-wide measurements such as of histone modification or DNA accessibility and output an annotation of genomic activity in the target cell type. Here we present annotations of 164 human cell types using 1615 data sets. To produce these annotations, we automated the label interpretation step to produce a fully automated annotation strategy. Using these annotations, we developed a measure of the importance of each genomic position called the âconservation-associated activity score.â We further combined all annotations into a single, cell type-agnostic encyclopedia that catalogs all human regulatory elements.
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Libbrecht, Maxwell; Rodriguez, Oscar; Weng, Zhiping; Bilmes, Jeffrey; Hoffman, Michael; Noble, William (2019). A unified encyclopedia of human functional DNA elements through fully automated annotation of 164 human cell types. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4647671
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AUTHORS (6)
ML
Maxwell Libbrecht
OR
Oscar Rodriguez
ZW
Zhiping Weng
JB
Jeffrey Bilmes
MH
Michael Hoffman
WN
William Noble